Crystallographic studies of pancreatic spasmolytic polypeptide
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چکیده
منابع مشابه
Oestrogen-induced pS2 protein is similar to pancreatic spasmolytic polypeptide and the kringle domain.
are oestrogen-dependent (Katzenellenbogen, 1980; McGuire, 1980). The MCF-7 cell line (Lippman & Bolan, 1975), a human breast cancer cell line, has been especially useful for understanding the mechanism of action of oestrogen. The pS2 protein (Mr 6500) is an abundant oestrogen-induced protein secreted by MCF-7 cells and found in breast tumour tissue (Masiokowski et al., 1982; Jakowlew et al., 19...
متن کاملPancreatic polypeptide.
Pancreatic polypeptide (PP) was discovered fortuitously during the purification of insulin from birds (Kimmel et al., 1968) and later from mammals (Chance et al., 1976). PP has since been extracted and purified from several mammalian species. It contains 36 amino-acid residues and is quite distinct from other known hormonal peptides (Lin and Chance, 1974). The amino-acid sequence of the peptide...
متن کاملPancreatic Polypeptide
Pancreatic Polypeptide (PP) is a 36 amino acid peptide produced and secreted by PP cells (originally termed F cells) of the pancreas which are primarily located in the Islets of Langerhans. It is part of a family of peptides that also includes Peptide YY (PYY) and Neuropeptide Y (NPY). PP is rapidly released after a meal but remains elevated for 4-6 hours in humans with the Vagus nerve being th...
متن کاملLeptin does not directly regulate the pancreatic hormones amylin and pancreatic polypeptide: interventional studies in humans.
OBJECTIVE Leptin and the pancreatic hormones amylin and pancreatic polypeptide are being evaluated alone or in combination for the treatment of obesity, but their physiological regulation has not yet been fully elucidated. Thus, we examined whether amylin and pancreatic polypeptide are regulated by caloric intake and/or short- and long-term energy deprivation and whether any potential regulatio...
متن کاملHeterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression.
OBJECTIVES Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To identify the commonalities and differences between phenotypic SPEM lineages, SPEM were studied from three different mouse models of parietal cell loss: with chronic inflammation with Helicobacter felis infection; with acute inflammati...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1993
ISSN: 0108-7673
DOI: 10.1107/s0108767378098025